Signalling and Bioactive Metabolites from Streptomyces sp. RK44
Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052Signalling and Bioactive Metabolites from Streptomyces sp. RK44
Auteurs : Qing Fang ; Fleurdeliz Maglangit [Philippines] ; Linrui Wu ; Rainer Ebel ; Kwaku Kyeremeh ; Jeanette H. Andersen ; Frederick Annang ; Guiomar Pérez-Moreno ; Fernando Reyes ; Hai DengSource :
- Molecules [ 1420-3049 ] ; 2020.
Abstract
Url:
DOI: 10.3390/molecules25030460
PubMed: 31979050
PubMed Central: 7037778
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000726
- to stream Pmc, to step Curation: 000726
- to stream Pmc, to step Checkpoint: 000046
- to stream Ncbi, to step Merge: 000E68
- to stream Ncbi, to step Curation: 000E68
- to stream Ncbi, to step Checkpoint: 000E68
- to stream Main, to step Merge: 000051
- to stream Main, to step Curation: 000051
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Signalling and Bioactive Metabolites from <italic>Streptomyces</italic> sp. RK44</title><author><name sortKey="Fang, Qing" sort="Fang, Qing" uniqKey="Fang Q" first="Qing" last="Fang">Qing Fang</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Maglangit, Fleurdeliz" sort="Maglangit, Fleurdeliz" uniqKey="Maglangit F" first="Fleurdeliz" last="Maglangit">Fleurdeliz Maglangit</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-molecules-25-00460">College of Science, Department of Biology and Environmental Science, University of the Philippines Cebu, Lahug, Cebu 6000, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>College of Science, Department of Biology and Environmental Science, University of the Philippines Cebu, Lahug, Cebu 6000</wicri:regionArea><wicri:noRegion>Cebu 6000</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Linrui" sort="Wu, Linrui" uniqKey="Wu L" first="Linrui" last="Wu">Linrui Wu</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Ebel, Rainer" sort="Ebel, Rainer" uniqKey="Ebel R" first="Rainer" last="Ebel">Rainer Ebel</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Kyeremeh, Kwaku" sort="Kyeremeh, Kwaku" uniqKey="Kyeremeh K" first="Kwaku" last="Kyeremeh">Kwaku Kyeremeh</name><affiliation><nlm:aff id="af3-molecules-25-00460">Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, P.O. Box LG56 Legon, Accra, Ghana;<email>kkyeremeh@ug.edu.gh</email></nlm:aff></affiliation></author><author><name sortKey="Andersen, Jeanette H" sort="Andersen, Jeanette H" uniqKey="Andersen J" first="Jeanette H." last="Andersen">Jeanette H. Andersen</name><affiliation><nlm:aff id="af4-molecules-25-00460">Marbio, UiT—The Arctic University of Norway, N-9037 Tromsø, Norway;<email>jeanette.h.andersen@uit.no</email></nlm:aff></affiliation></author><author><name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name><affiliation><nlm:aff id="af5-molecules-25-00460">Fundación MEDINA, Avda. del Conocimiento 34, 18016 Armilla, Granada, Spain;<email>freddie.annang@medinaandalucia.es</email> (F.A.);<email>fernando.reyes@medinaandalucia.es</email> (F.R.)</nlm:aff></affiliation></author><author><name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name><affiliation><nlm:aff id="af6-molecules-25-00460">Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento 17, 18016 Armilla, Granada, Spain;<email>guiomar@ipb.csic.es</email></nlm:aff></affiliation></author><author><name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name><affiliation><nlm:aff id="af5-molecules-25-00460">Fundación MEDINA, Avda. del Conocimiento 34, 18016 Armilla, Granada, Spain;<email>freddie.annang@medinaandalucia.es</email> (F.A.);<email>fernando.reyes@medinaandalucia.es</email> (F.R.)</nlm:aff></affiliation></author><author><name sortKey="Deng, Hai" sort="Deng, Hai" uniqKey="Deng H" first="Hai" last="Deng">Hai Deng</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31979050</idno><idno type="pmc">7037778</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037778</idno><idno type="RBID">PMC:7037778</idno><idno type="doi">10.3390/molecules25030460</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000726</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000726</idno><idno type="wicri:Area/Pmc/Curation">000726</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000726</idno><idno type="wicri:Area/Pmc/Checkpoint">000046</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000046</idno><idno type="wicri:Area/Ncbi/Merge">000E68</idno><idno type="wicri:Area/Ncbi/Curation">000E68</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E68</idno><idno type="wicri:Area/Main/Merge">000051</idno><idno type="wicri:Area/Main/Curation">000051</idno><idno type="wicri:Area/Main/Exploration">000051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Signalling and Bioactive Metabolites from <italic>Streptomyces</italic> sp. RK44</title><author><name sortKey="Fang, Qing" sort="Fang, Qing" uniqKey="Fang Q" first="Qing" last="Fang">Qing Fang</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Maglangit, Fleurdeliz" sort="Maglangit, Fleurdeliz" uniqKey="Maglangit F" first="Fleurdeliz" last="Maglangit">Fleurdeliz Maglangit</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-molecules-25-00460">College of Science, Department of Biology and Environmental Science, University of the Philippines Cebu, Lahug, Cebu 6000, Philippines</nlm:aff><country xml:lang="fr">Philippines</country><wicri:regionArea>College of Science, Department of Biology and Environmental Science, University of the Philippines Cebu, Lahug, Cebu 6000</wicri:regionArea><wicri:noRegion>Cebu 6000</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Linrui" sort="Wu, Linrui" uniqKey="Wu L" first="Linrui" last="Wu">Linrui Wu</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Ebel, Rainer" sort="Ebel, Rainer" uniqKey="Ebel R" first="Rainer" last="Ebel">Rainer Ebel</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author><author><name sortKey="Kyeremeh, Kwaku" sort="Kyeremeh, Kwaku" uniqKey="Kyeremeh K" first="Kwaku" last="Kyeremeh">Kwaku Kyeremeh</name><affiliation><nlm:aff id="af3-molecules-25-00460">Marine and Plant Research Laboratory of Ghana, Department of Chemistry, University of Ghana, P.O. Box LG56 Legon, Accra, Ghana;<email>kkyeremeh@ug.edu.gh</email></nlm:aff></affiliation></author><author><name sortKey="Andersen, Jeanette H" sort="Andersen, Jeanette H" uniqKey="Andersen J" first="Jeanette H." last="Andersen">Jeanette H. Andersen</name><affiliation><nlm:aff id="af4-molecules-25-00460">Marbio, UiT—The Arctic University of Norway, N-9037 Tromsø, Norway;<email>jeanette.h.andersen@uit.no</email></nlm:aff></affiliation></author><author><name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name><affiliation><nlm:aff id="af5-molecules-25-00460">Fundación MEDINA, Avda. del Conocimiento 34, 18016 Armilla, Granada, Spain;<email>freddie.annang@medinaandalucia.es</email> (F.A.);<email>fernando.reyes@medinaandalucia.es</email> (F.R.)</nlm:aff></affiliation></author><author><name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name><affiliation><nlm:aff id="af6-molecules-25-00460">Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento 17, 18016 Armilla, Granada, Spain;<email>guiomar@ipb.csic.es</email></nlm:aff></affiliation></author><author><name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name><affiliation><nlm:aff id="af5-molecules-25-00460">Fundación MEDINA, Avda. del Conocimiento 34, 18016 Armilla, Granada, Spain;<email>freddie.annang@medinaandalucia.es</email> (F.A.);<email>fernando.reyes@medinaandalucia.es</email> (F.R.)</nlm:aff></affiliation></author><author><name sortKey="Deng, Hai" sort="Deng, Hai" uniqKey="Deng H" first="Hai" last="Deng">Hai Deng</name><affiliation><nlm:aff id="af1-molecules-25-00460">Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK;<email>r01qf16@abdn.ac.uk</email> (Q.F.);<email>r01fm16@abdn.ac.uk</email> (F.M.);<email>r03lw15@abdn.ac.uk</email> (L.W.);<email>r.ebel@abdn.ac.uk</email> (R.E.)</nlm:aff></affiliation></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Streptomyces</italic> remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of <italic>Streptomyces</italic> sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the characterization of a new 2-alkyl-4-hydroxymethylfuran carboxamide (AHFA) <bold>1</bold> together with five known compounds, cyclo-(L-Pro-Gly) <bold>2</bold>, cyclo-(L-Pro-L-Phe) <bold>3</bold>, cyclo-(L-Pro-L-Val) <bold>4</bold>, cyclo-(L-Leu-Hyp) <bold>5</bold>, and deferoxamine E <bold>6</bold>. AHFA <bold>1</bold>, a methylenomycin (MMF) homolog, exhibited anti-proliferative activity (EC<sub>50</sub> = 89.6 µM) against melanoma A2058 cell lines. This activity, albeit weak is the first report amongst MMFs. Furthermore, the putative biosynthetic gene cluster (<italic>ahfa</italic>) was identified for the biosynthesis of AHFA <bold>1</bold>. DFO-E <bold>6</bold> displayed potent anti-plasmodial activity (IC<sub>50</sub> = 1.08 µM) against <italic>P. falciparum</italic> 3D7. High-resolution electrospray ionization mass spectrometry (HR ESIMS) and molecular network assisted the targeted-isolation process, and tentatively identified six AHFA analogues, <bold>7</bold>–<bold>12</bold> and six siderophores <bold>13</bold>–<bold>18</bold>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Eliakim Raz, N" uniqKey="Eliakim Raz N">N. Eliakim-Raz</name></author><author><name sortKey="Lador, A" uniqKey="Lador A">A. Lador</name></author><author><name sortKey="Leibovici Weissman, Y" uniqKey="Leibovici Weissman Y">Y. Leibovici-Weissman</name></author><author><name sortKey="Elbaz, M" uniqKey="Elbaz M">M. Elbaz</name></author><author><name sortKey="Paul, M" uniqKey="Paul M">M. Paul</name></author><author><name sortKey="Leibovici, L" uniqKey="Leibovici L">L. Leibovici</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falagas, M E" uniqKey="Falagas M">M.E. Falagas</name></author><author><name sortKey="Vouloumanou, E K" uniqKey="Vouloumanou E">E.K. Vouloumanou</name></author><author><name sortKey="Samonis, G" uniqKey="Samonis G">G. Samonis</name></author><author><name sortKey="Vardakas, K Z" uniqKey="Vardakas K">K.Z. Vardakas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vons, C" uniqKey="Vons C">C. Vons</name></author><author><name sortKey="Barry, C" uniqKey="Barry C">C. Barry</name></author><author><name sortKey="Maitre, S" uniqKey="Maitre S">S. Maitre</name></author><author><name sortKey="Pautrat, K" uniqKey="Pautrat K">K. Pautrat</name></author><author><name sortKey="Leconte, M" uniqKey="Leconte M">M. Leconte</name></author><author><name sortKey="Costaglioli, B" uniqKey="Costaglioli B">B. Costaglioli</name></author><author><name sortKey="Karoui, M" uniqKey="Karoui M">M. Karoui</name></author><author><name sortKey="Alves, A" uniqKey="Alves A">A. Alves</name></author><author><name sortKey="Dousset, B" uniqKey="Dousset B">B. Dousset</name></author><author><name sortKey="Valleur, P" uniqKey="Valleur P">P. Valleur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitani, S" uniqKey="Kitani S">S. Kitani</name></author><author><name sortKey="Miyamoto, K T" uniqKey="Miyamoto K">K.T. Miyamoto</name></author><author><name sortKey="Takamatsu, S" uniqKey="Takamatsu S">S. Takamatsu</name></author><author><name sortKey="Herawati, E" uniqKey="Herawati E">E. Herawati</name></author><author><name sortKey="Iguchi, H" uniqKey="Iguchi H">H. Iguchi</name></author><author><name sortKey="Nishitomi, K" uniqKey="Nishitomi K">K. Nishitomi</name></author><author><name sortKey="Uchida, M" uniqKey="Uchida M">M. Uchida</name></author><author><name sortKey="Nagamitsu, T" uniqKey="Nagamitsu T">T. Nagamitsu</name></author><author><name sortKey="Omura, S" uniqKey="Omura S">S. Omura</name></author><author><name sortKey="Ikeda, H" uniqKey="Ikeda H">H. Ikeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maglangit, F" uniqKey="Maglangit F">F. Maglangit</name></author><author><name sortKey="Fang, Q" uniqKey="Fang Q">Q. Fang</name></author><author><name sortKey="Leman, V" uniqKey="Leman V">V. Leman</name></author><author><name sortKey="Soldatou, S" uniqKey="Soldatou S">S. Soldatou</name></author><author><name sortKey="Ebel, R" uniqKey="Ebel R">R. Ebel</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H. Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maglangit, F" uniqKey="Maglangit F">F. Maglangit</name></author><author><name sortKey="Fang, Q" uniqKey="Fang Q">Q. Fang</name></author><author><name sortKey="Kyeremeh, K" uniqKey="Kyeremeh K">K. Kyeremeh</name></author><author><name sortKey="Sternberg, J M" uniqKey="Sternberg J">J.M. Sternberg</name></author><author><name sortKey="Ebel, R" uniqKey="Ebel R">R. Ebel</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H. Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Carver, J J" uniqKey="Carver J">J.J. Carver</name></author><author><name sortKey="Phelan, V V" uniqKey="Phelan V">V.V. Phelan</name></author><author><name sortKey="Sanchez, L M" uniqKey="Sanchez L">L.M. Sanchez</name></author><author><name sortKey="Garg, N" uniqKey="Garg N">N. Garg</name></author><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name></author><author><name sortKey="Nguyen, D D" uniqKey="Nguyen D">D.D. Nguyen</name></author><author><name sortKey="Watrous, J" uniqKey="Watrous J">J. Watrous</name></author><author><name sortKey="Kapono, C A" uniqKey="Kapono C">C.A. Kapono</name></author><author><name sortKey="Luzzatto Knaan, T" uniqKey="Luzzatto Knaan T">T. Luzzatto-Knaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santen, J" uniqKey="Santen J">J. Santen</name></author><author><name sortKey="Van, A" uniqKey="Van A">A. Van</name></author><author><name sortKey="Jacob, G" uniqKey="Jacob G">G. Jacob</name></author><author><name sortKey="Singh, A L" uniqKey="Singh A">A.L. Singh</name></author><author><name sortKey="Aniebok, V" uniqKey="Aniebok V">V. Aniebok</name></author><author><name sortKey="Balunas, M J" uniqKey="Balunas M">M.J. Balunas</name></author><author><name sortKey="Bunsko, D" uniqKey="Bunsko D">D. Bunsko</name></author><author><name sortKey="Neto, F C" uniqKey="Neto F">F.C. Neto</name></author><author><name sortKey="Casta O Espriu, L" uniqKey="Casta O Espriu L">L. Castaño-Espriu</name></author><author><name sortKey="Chang, C" uniqKey="Chang C">C. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pence, H E" uniqKey="Pence H">H.E. Pence</name></author><author><name sortKey="Williams, A" uniqKey="Williams A">A. Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, T" uniqKey="Ito T">T. Ito</name></author><author><name sortKey="Masubuchi, M" uniqKey="Masubuchi M">M. Masubuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crusemann, M" uniqKey="Crusemann M">M. Crüsemann</name></author><author><name sortKey="O Eill, E C" uniqKey="O Eill E">E.C. O’Neill</name></author><author><name sortKey="Larson, C B" uniqKey="Larson C">C.B. Larson</name></author><author><name sortKey="Melnik, A V" uniqKey="Melnik A">A.V. Melnik</name></author><author><name sortKey="Floros, D J" uniqKey="Floros D">D.J. Floros</name></author><author><name sortKey="Da Silva, R R" uniqKey="Da Silva R">R.R. Da Silva</name></author><author><name sortKey="Jensen, P R" uniqKey="Jensen P">P.R. Jensen</name></author><author><name sortKey="Dorrestein, P C" uniqKey="Dorrestein P">P.C. Dorrestein</name></author><author><name sortKey="Moore, B S" uniqKey="Moore B">B.S. Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corre, C" uniqKey="Corre C">C. Corre</name></author><author><name sortKey="Song, L" uniqKey="Song L">L. Song</name></author><author><name sortKey="O Ourke, S" uniqKey="O Ourke S">S. O’Rourke</name></author><author><name sortKey="Chater, K F" uniqKey="Chater K">K.F. Chater</name></author><author><name sortKey="Challis, G L" uniqKey="Challis G">G.L. Challis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuster, M" uniqKey="Schuster M">M. Schuster</name></author><author><name sortKey="Joseph Sexton, D" uniqKey="Joseph Sexton D">D. Joseph Sexton</name></author><author><name sortKey="Diggle, S P" uniqKey="Diggle S">S.P. Diggle</name></author><author><name sortKey="Peter Greenberg, E" uniqKey="Peter Greenberg E">E. Peter Greenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidda, J D" uniqKey="Sidda J">J.D. Sidda</name></author><author><name sortKey="Poon, V" uniqKey="Poon V">V. Poon</name></author><author><name sortKey="Song, L" uniqKey="Song L">L. Song</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Yang, K" uniqKey="Yang K">K. Yang</name></author><author><name sortKey="Corre, C" uniqKey="Corre C">C. Corre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, Y L" uniqKey="Du Y">Y.L. Du</name></author><author><name sortKey="Shen, X L" uniqKey="Shen X">X.L. Shen</name></author><author><name sortKey="Yu, P" uniqKey="Yu P">P. Yu</name></author><author><name sortKey="Bai, L Q" uniqKey="Bai L">L.Q. Bai</name></author><author><name sortKey="Li, Y Q" uniqKey="Li Y">Y.Q. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhasin, S" uniqKey="Bhasin S">S. Bhasin</name></author><author><name sortKey="Modi, H A" uniqKey="Modi H">H.A. Modi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Dobretsov, S" uniqKey="Dobretsov S">S. Dobretsov</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Xiao, X" uniqKey="Xiao X">X. Xiao</name></author><author><name sortKey="Hung, O" uniqKey="Hung O">O. Hung</name></author><author><name sortKey="Qian, P Y" uniqKey="Qian P">P.Y. Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campo, V L" uniqKey="Campo V">V.L. Campo</name></author><author><name sortKey="Duarte, M C T" uniqKey="Duarte M">M.C.T. Duarte</name></author><author><name sortKey="Bastos, J K" uniqKey="Bastos J">J.K. Bastos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S R" uniqKey="Lee S">S.R. Lee</name></author><author><name sortKey="Beemelmanns, C" uniqKey="Beemelmanns C">C. Beemelmanns</name></author><author><name sortKey="Tsuma, L M M" uniqKey="Tsuma L">L.M.M. Tsuma</name></author><author><name sortKey="Clardy, J" uniqKey="Clardy J">J. Clardy</name></author><author><name sortKey="Cao, S" uniqKey="Cao S">S. Cao</name></author><author><name sortKey="Kim, K H" uniqKey="Kim K">K.H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alshaibani, M" uniqKey="Alshaibani M">M. Alshaibani</name></author><author><name sortKey="Jalil, J" uniqKey="Jalil J">J. Jalil</name></author><author><name sortKey="Sidik, N" uniqKey="Sidik N">N. Sidik</name></author><author><name sortKey="Ahmad, S" uniqKey="Ahmad S">S. Ahmad</name></author><author><name sortKey="Kamal, N" uniqKey="Kamal N">N. Kamal</name></author><author><name sortKey="Edrada Ebel, R" uniqKey="Edrada Ebel R">R. Edrada-Ebel</name></author><author><name sortKey="Mohamadzin, N" uniqKey="Mohamadzin N">N. MohamadZin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishanth Kumar, S" uniqKey="Nishanth Kumar S">S. Nishanth Kumar</name></author><author><name sortKey="Mohandas, C" uniqKey="Mohandas C">C. Mohandas</name></author><author><name sortKey="Siji, J V" uniqKey="Siji J">J.V. Siji</name></author><author><name sortKey="Rajasekharan, K N" uniqKey="Rajasekharan K">K.N. Rajasekharan</name></author><author><name sortKey="Nambisan, B" uniqKey="Nambisan B">B. Nambisan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maglangit, F" uniqKey="Maglangit F">F. Maglangit</name></author><author><name sortKey="Tong, M H" uniqKey="Tong M">M.H. Tong</name></author><author><name sortKey="Jaspars, M" uniqKey="Jaspars M">M. Jaspars</name></author><author><name sortKey="Kyeremeh, K" uniqKey="Kyeremeh K">K. Kyeremeh</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H. Deng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamanaka, K" uniqKey="Yamanaka K">K. Yamanaka</name></author><author><name sortKey="Oikawa, H" uniqKey="Oikawa H">H. Oikawa</name></author><author><name sortKey="Ogawa, H O" uniqKey="Ogawa H">H.O. Ogawa</name></author><author><name sortKey="Hosono, K" uniqKey="Hosono K">K. Hosono</name></author><author><name sortKey="Shinmachi, F" uniqKey="Shinmachi F">F. Shinmachi</name></author><author><name sortKey="Takano, H" uniqKey="Takano H">H. Takano</name></author><author><name sortKey="Sakuda, S" uniqKey="Sakuda S">S. Sakuda</name></author><author><name sortKey="Beppu, T" uniqKey="Beppu T">T. Beppu</name></author><author><name sortKey="Ueda, K" uniqKey="Ueda K">K. Ueda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meiwes, J" uniqKey="Meiwes J">J. Meiwes</name></author><author><name sortKey="Fiedler, H P" uniqKey="Fiedler H">H.P. Fiedler</name></author><author><name sortKey="Z Hner, H" uniqKey="Z Hner H">H. Zähner</name></author><author><name sortKey="Konetschny Rapp, S" uniqKey="Konetschny Rapp S">S. Konetschny-Rapp</name></author><author><name sortKey="Jung, G" uniqKey="Jung G">G. Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corre, C" uniqKey="Corre C">C. Corre</name></author><author><name sortKey="Haynes, S W" uniqKey="Haynes S">S.W. Haynes</name></author><author><name sortKey="Malet, N" uniqKey="Malet N">N. Malet</name></author><author><name sortKey="Song, L" uniqKey="Song L">L. Song</name></author><author><name sortKey="Challis, G L" uniqKey="Challis G">G.L. Challis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, T" uniqKey="Weber T">T. Weber</name></author><author><name sortKey="Blin, K" uniqKey="Blin K">K. Blin</name></author><author><name sortKey="Duddela, S" uniqKey="Duddela S">S. Duddela</name></author><author><name sortKey="Krug, D" uniqKey="Krug D">D. Krug</name></author><author><name sortKey="Kim, H U" uniqKey="Kim H">H.U. Kim</name></author><author><name sortKey="Bruccoleri, R" uniqKey="Bruccoleri R">R. Bruccoleri</name></author><author><name sortKey="Lee, S Y" uniqKey="Lee S">S.Y. Lee</name></author><author><name sortKey="Fischbach, M A" uniqKey="Fischbach M">M.A. Fischbach</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R. Müller</name></author><author><name sortKey="Wohlleben, W" uniqKey="Wohlleben W">W. Wohlleben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sayers, E W" uniqKey="Sayers E">E.W. Sayers</name></author><author><name sortKey="Agarwala, R" uniqKey="Agarwala R">R. Agarwala</name></author><author><name sortKey="Bolton, E E" uniqKey="Bolton E">E.E. Bolton</name></author><author><name sortKey="Brister, J R" uniqKey="Brister J">J.R. Brister</name></author><author><name sortKey="Canese, K" uniqKey="Canese K">K. Canese</name></author><author><name sortKey="Clark, K" uniqKey="Clark K">K. Clark</name></author><author><name sortKey="Connor, R" uniqKey="Connor R">R. Connor</name></author><author><name sortKey="Fiorini, N" uniqKey="Fiorini N">N. Fiorini</name></author><author><name sortKey="Funk, K" uniqKey="Funk K">K. Funk</name></author><author><name sortKey="Hefferon, T" uniqKey="Hefferon T">T. Hefferon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zallot, R" uniqKey="Zallot R">R. Zallot</name></author><author><name sortKey="Oberg, N O" uniqKey="Oberg N">N.O. Oberg</name></author><author><name sortKey="Gerlt, J A" uniqKey="Gerlt J">J.A. Gerlt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horinouchi, S" uniqKey="Horinouchi S">S. Horinouchi</name></author><author><name sortKey="Beppu, T" uniqKey="Beppu T">T. Beppu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, J B" uniqKey="Davis J">J.B. Davis</name></author><author><name sortKey="Bailey, J D" uniqKey="Bailey J">J.D. Bailey</name></author><author><name sortKey="Sello, J K" uniqKey="Sello J">J.K. Sello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alberti, F" uniqKey="Alberti F">F. Alberti</name></author><author><name sortKey="Leng, D J" uniqKey="Leng D">D.J. Leng</name></author><author><name sortKey="Wilkening, I" uniqKey="Wilkening I">I. Wilkening</name></author><author><name sortKey="Song, L" uniqKey="Song L">L. Song</name></author><author><name sortKey="Tosin, M" uniqKey="Tosin M">M. Tosin</name></author><author><name sortKey="Corre, C" uniqKey="Corre C">C. Corre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordeuk, V R" uniqKey="Gordeuk V">V.R. Gordeuk</name></author><author><name sortKey="Thuma, P E" uniqKey="Thuma P">P.E. Thuma</name></author><author><name sortKey="Brittenbam, G M" uniqKey="Brittenbam G">G.M. Brittenbam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rotheneder, A" uniqKey="Rotheneder A">A. Rotheneder</name></author><author><name sortKey="Fritsche, G" uniqKey="Fritsche G">G. Fritsche</name></author><author><name sortKey="Heinisch, L" uniqKey="Heinisch L">L. Heinisch</name></author><author><name sortKey="Heggemann, S" uniqKey="Heggemann S">S. Heggemann</name></author><author><name sortKey="Larcher, C" uniqKey="Larcher C">C. Larcher</name></author><author><name sortKey="Mollmann, U" uniqKey="Mollmann U">U. Möllmann</name></author><author><name sortKey="Weiss, G" uniqKey="Weiss G">G. Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrer, P" uniqKey="Ferrer P">P. Ferrer</name></author><author><name sortKey="Tripathi, A K" uniqKey="Tripathi A">A.K. Tripathi</name></author><author><name sortKey="Clark, M A" uniqKey="Clark M">M.A. Clark</name></author><author><name sortKey="Hand, C C" uniqKey="Hand C">C.C. Hand</name></author><author><name sortKey="Rienhoff, H Y" uniqKey="Rienhoff H">H.Y. Rienhoff</name></author><author><name sortKey="Sullivan, D J" uniqKey="Sullivan D">D.J. Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pradines, B" uniqKey="Pradines B">B. Pradines</name></author><author><name sortKey="Rolain, J M" uniqKey="Rolain J">J.M. Rolain</name></author><author><name sortKey="Ramiandrasoa, F" uniqKey="Ramiandrasoa F">F. Ramiandrasoa</name></author><author><name sortKey="Fusai, T" uniqKey="Fusai T">T. Fusai</name></author><author><name sortKey="Mosnier, J" uniqKey="Mosnier J">J. Mosnier</name></author><author><name sortKey="Rogier, C" uniqKey="Rogier C">C. Rogier</name></author><author><name sortKey="Daries, W" uniqKey="Daries W">W. Daries</name></author><author><name sortKey="Baret, E" uniqKey="Baret E">E. Baret</name></author><author><name sortKey="Kunesch, G" uniqKey="Kunesch G">G. Kunesch</name></author><author><name sortKey="Le Bras, J" uniqKey="Le Bras J">J. Le Bras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Moreno, G" uniqKey="Perez Moreno G">G. Pérez-Moreno</name></author><author><name sortKey="Cantizani, J" uniqKey="Cantizani J">J. Cantizani</name></author><author><name sortKey="Sanchez Carrasco, P" uniqKey="Sanchez Carrasco P">P. Sánchez-Carrasco</name></author><author><name sortKey="Ruiz Perez, L M" uniqKey="Ruiz Perez L">L.M. Ruiz-Pérez</name></author><author><name sortKey="Martin, J" uniqKey="Martin J">J. Martín</name></author><author><name sortKey="El Aouad, N" uniqKey="El Aouad N">N. El Aouad</name></author><author><name sortKey="Perez Victoria, I" uniqKey="Perez Victoria I">I. Pérez-Victoria</name></author><author><name sortKey="Tormo, J R" uniqKey="Tormo J">J.R. Tormo</name></author><author><name sortKey="Gonzalez Menendez, V" uniqKey="Gonzalez Menendez V">V. González-Menendez</name></author><author><name sortKey="Gonzalez, I" uniqKey="Gonzalez I">I. González</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pluskal, T" uniqKey="Pluskal T">T. Pluskal</name></author><author><name sortKey="Castillo, S" uniqKey="Castillo S">S. Castillo</name></author><author><name sortKey="Villar Briones, A" uniqKey="Villar Briones A">A. Villar-Briones</name></author><author><name sortKey="Oresi, M" uniqKey="Oresi M">M. Orešič</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pylayeva Gupta, Y" uniqKey="Pylayeva Gupta Y">Y. Pylayeva-Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shannon, P" uniqKey="Shannon P">P. Shannon</name></author><author><name sortKey="Markiel, A" uniqKey="Markiel A">A. Markiel</name></author><author><name sortKey="Ozier, O" uniqKey="Ozier O">O. Ozier</name></author><author><name sortKey="Baliga, N S" uniqKey="Baliga N">N.S. Baliga</name></author><author><name sortKey="Wang, J T" uniqKey="Wang J">J.T. Wang</name></author><author><name sortKey="Ramage, D" uniqKey="Ramage D">D. Ramage</name></author><author><name sortKey="Amin, N" uniqKey="Amin N">N. Amin</name></author><author><name sortKey="Schwikowski, B" uniqKey="Schwikowski B">B. Schwikowski</name></author><author><name sortKey="Ideker, T" uniqKey="Ideker T">T. Ideker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aziz, R K" uniqKey="Aziz R">R.K. Aziz</name></author><author><name sortKey="Bartels, D" uniqKey="Bartels D">D. Bartels</name></author><author><name sortKey="Best, A A" uniqKey="Best A">A.A. Best</name></author><author><name sortKey="Dejongh, M" uniqKey="Dejongh M">M. DeJongh</name></author><author><name sortKey="Disz, T" uniqKey="Disz T">T. Disz</name></author><author><name sortKey="Edwards, R A" uniqKey="Edwards R">R.A. Edwards</name></author><author><name sortKey="Formsma, K" uniqKey="Formsma K">K. Formsma</name></author><author><name sortKey="Gerdes, S" uniqKey="Gerdes S">S. Gerdes</name></author><author><name sortKey="Glass, E M" uniqKey="Glass E">E.M. Glass</name></author><author><name sortKey="Kubal, M" uniqKey="Kubal M">M. Kubal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saitou, N" uniqKey="Saitou N">N. Saitou</name></author><author><name sortKey="Nei, M" uniqKey="Nei M">M. Nei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Stecher, G" uniqKey="Stecher G">G. Stecher</name></author><author><name sortKey="Tamura, K" uniqKey="Tamura K">K. Tamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carpenter, D E" uniqKey="Carpenter D">D.E. Carpenter</name></author><author><name sortKey="Karen Anderson Diane Citron, C M" uniqKey="Karen Anderson Diane Citron C">C.M. Karen Anderson Diane Citron</name></author><author><name sortKey="Joann Dzink Fox, B L" uniqKey="Joann Dzink Fox B">B.L. JoAnn Dzink-Fox</name></author><author><name sortKey="Meredith Hackel, M" uniqKey="Meredith Hackel M">M. Meredith Hackel</name></author><author><name sortKey="Jenkins, S G" uniqKey="Jenkins S">S.G. Jenkins</name></author><author><name sortKey="Cindy Knapp, F" uniqKey="Cindy Knapp F">F. Cindy Knapp</name></author><author><name sortKey="Laura Koeth, M" uniqKey="Laura Koeth M">M. Laura Koeth</name></author><author><name sortKey="Audrey Schuetz, M N" uniqKey="Audrey Schuetz M">M.N. Audrey Schuetz</name></author><author><name sortKey="Hannah Wexler, D" uniqKey="Hannah Wexler D">D. Hannah Wexler</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Philippines</li></country></list><tree><noCountry><name sortKey="Andersen, Jeanette H" sort="Andersen, Jeanette H" uniqKey="Andersen J" first="Jeanette H." last="Andersen">Jeanette H. Andersen</name><name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name><name sortKey="Deng, Hai" sort="Deng, Hai" uniqKey="Deng H" first="Hai" last="Deng">Hai Deng</name><name sortKey="Ebel, Rainer" sort="Ebel, Rainer" uniqKey="Ebel R" first="Rainer" last="Ebel">Rainer Ebel</name><name sortKey="Fang, Qing" sort="Fang, Qing" uniqKey="Fang Q" first="Qing" last="Fang">Qing Fang</name><name sortKey="Kyeremeh, Kwaku" sort="Kyeremeh, Kwaku" uniqKey="Kyeremeh K" first="Kwaku" last="Kyeremeh">Kwaku Kyeremeh</name><name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name><name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name><name sortKey="Wu, Linrui" sort="Wu, Linrui" uniqKey="Wu L" first="Linrui" last="Wu">Linrui Wu</name></noCountry><country name="Philippines"><noRegion><name sortKey="Maglangit, Fleurdeliz" sort="Maglangit, Fleurdeliz" uniqKey="Maglangit F" first="Fleurdeliz" last="Maglangit">Fleurdeliz Maglangit</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000051 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000051 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7037778
|texte= Signalling and Bioactive Metabolites from Streptomyces sp. RK44
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31979050" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |